Denosumab for the prevention of skeletal complications in metastatic castration-resistant prostate cancer: comparison of skeletal-related events and symptomatic skeletal events
Identifieur interne : 003A54 ( Main/Exploration ); précédent : 003A53; suivant : 003A55Denosumab for the prevention of skeletal complications in metastatic castration-resistant prostate cancer: comparison of skeletal-related events and symptomatic skeletal events
Auteurs : M. R. Smith [États-Unis] ; R. E. Coleman [Royaume-Uni] ; L. Klotz [Canada] ; K. Pittman [Australie] ; P. Milecki [Pologne] ; S. Ng [Australie] ; K. N. Chi [Canada] ; A. Balakumaran ; R. Wei [États-Unis] ; H. Wang [États-Unis] ; A. Braun ; K. Fizazi [France]Source :
- Annals of Oncology [ 0923-7534 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Tumeurs prostatiques résistantes à la castration.
- secondaire : Tumeurs osseuses.
- usage thérapeutique : Agents de maintien de la densité osseuse, Dénosumab.
- Adulte d'âge moyen, Humains, Mâle, Méthode en double aveugle, Sujet âgé, Tumeurs osseuses.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Bone Density Conservation Agents, Denosumab.
- complications : Bone Neoplasms.
- pathology : Prostatic Neoplasms, Castration-Resistant.
- secondary : Bone Neoplasms.
- Aged, Double-Blind Method, Humans, Male, Middle Aged.
Abstract
In this analysis of a phase III trial in patients with castration-resistant prostate cancer and bone metastases, treatment with denosumab reduced the risk of skeletal complications vs zoledronic acid regardless of whether the end point was defined as SSE or SRE. Both SSEs and SREs were associated with development of moderate/severe pain among patients with no/mild pain at baseline.
Url:
DOI: 10.1093/annonc/mdu519
PubMed: 25425475
PubMed Central: 4304378
Affiliations:
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R." last="Smith">M. R. Smith</name><affiliation wicri:level="1"><nlm:aff id="mdu519_af1"><addr-line>Department of Hematology/Oncology</addr-line>,<institution>Massachusetts General Hospital Cancer Center</institution>,<addr-line>Boston</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coleman, R E" sort="Coleman, R E" uniqKey="Coleman R" first="R. E." last="Coleman">R. E. Coleman</name><affiliation wicri:level="1"><nlm:aff id="mdu519_af2"><addr-line>Academic Unit of Clinical Oncology</addr-line>,<institution>Sheffield Cancer Research Centre</institution>,<addr-line>Sheffield</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Klotz, L" sort="Klotz, L" uniqKey="Klotz L" first="L." last="Klotz">L. Klotz</name><affiliation wicri:level="1"><nlm:aff id="mdu519_af3"><addr-line>Division of Urology</addr-line>,<institution>Sunnybrook and Women's College Health Sciences Centre</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pittman, K" sort="Pittman, K" uniqKey="Pittman K" first="K." last="Pittman">K. Pittman</name><affiliation wicri:level="1"><nlm:aff id="mdu519_af4"><addr-line>Department of Medical Oncology</addr-line>,<institution>The Queen Elizabeth Hospital</institution>,<addr-line>Woodville</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milecki, P" sort="Milecki, P" uniqKey="Milecki P" first="P." last="Milecki">P. Milecki</name><affiliation><nlm:aff id="mdu519_af5"><addr-line>Department of Electroradiology</addr-line>,<institution>Poznan University of Medical Sciences</institution>,<addr-line>Poznan</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="mdu519_af6"><addr-line>Department of Radiotherapy</addr-line>,<institution>Wielkopolskie Centrum Onkologii</institution>,<addr-line>Poznan</addr-line>,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ng, S" sort="Ng, S" uniqKey="Ng S" first="S." last="Ng">S. Ng</name><affiliation wicri:level="1"><nlm:aff id="mdu519_af7"><institution>St John of God Hospital</institution>,<addr-line>Subiaco</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chi, K N" sort="Chi, K N" uniqKey="Chi K" first="K. N." last="Chi">K. N. Chi</name><affiliation wicri:level="1"><nlm:aff id="mdu519_af8"><addr-line>Department of Medical Oncology</addr-line>,<institution>BC Cancer Agency</institution>,<addr-line>Vancouver</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Balakumaran, A" sort="Balakumaran, A" uniqKey="Balakumaran A" first="A." last="Balakumaran">A. Balakumaran</name><affiliation><nlm:aff id="mdu519_af9"><addr-line>Department of Hematology/Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wei, R" sort="Wei, R" uniqKey="Wei R" first="R." last="Wei">R. Wei</name><affiliation wicri:level="1"><nlm:aff id="mdu519_af10"><addr-line>Global Biostatistical Science</addr-line>,<institution>Amgen Inc.</institution>,<addr-line>Thousand Oaks</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, H" sort="Wang, H" uniqKey="Wang H" first="H." last="Wang">H. Wang</name><affiliation wicri:level="1"><nlm:aff id="mdu519_af10"><addr-line>Global Biostatistical Science</addr-line>,<institution>Amgen Inc.</institution>,<addr-line>Thousand Oaks</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Braun, A" sort="Braun, A" uniqKey="Braun A" first="A." last="Braun">A. Braun</name><affiliation><nlm:aff id="mdu519_af9"><addr-line>Department of Hematology/Oncology</addr-line></nlm:aff></affiliation></author><author><name sortKey="Fizazi, K" sort="Fizazi, K" uniqKey="Fizazi K" first="K." last="Fizazi">K. Fizazi</name><affiliation wicri:level="1"><nlm:aff id="mdu519_af11"><addr-line>Department of Medical Oncology</addr-line>,<institution>Institut Gustave Roussy, University of Paris Sud</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of Oncology</title><idno type="ISSN">0923-7534</idno><idno type="eISSN">1569-8041</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Bone Density Conservation Agents (therapeutic use)</term><term>Bone Neoplasms (complications)</term><term>Bone Neoplasms (secondary)</term><term>Denosumab (therapeutic use)</term><term>Double-Blind Method</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prostatic Neoplasms, Castration-Resistant (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Agents de maintien de la densité osseuse (usage thérapeutique)</term><term>Dénosumab (usage thérapeutique)</term><term>Humains</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Sujet âgé</term><term>Tumeurs osseuses ()</term><term>Tumeurs osseuses (secondaire)</term><term>Tumeurs prostatiques résistantes à la castration (anatomopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Bone Density Conservation Agents</term><term>Denosumab</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs prostatiques résistantes à la castration</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Bone Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Prostatic Neoplasms, Castration-Resistant</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs osseuses</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Bone Neoplasms</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents de maintien de la densité osseuse</term><term>Dénosumab</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Double-Blind Method</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Humains</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Sujet âgé</term><term>Tumeurs osseuses</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In this analysis of a phase III trial in patients with castration-resistant prostate cancer and bone metastases, treatment with denosumab reduced the risk of skeletal complications vs zoledronic acid regardless of whether the end point was defined as SSE or SRE. Both SSEs and SREs were associated with development of moderate/severe pain among patients with no/mild pain at baseline.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Saylor, Pj" uniqKey="Saylor P">PJ Saylor</name></author><author><name sortKey="Armstrong, Aj" uniqKey="Armstrong A">AJ Armstrong</name></author><author><name sortKey="Fizazi, K" uniqKey="Fizazi K">K Fizazi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bubendorf, L" uniqKey="Bubendorf L">L Bubendorf</name></author><author><name sortKey="Schopfer, A" uniqKey="Schopfer A">A Schopfer</name></author><author><name sortKey="Wagner, U" uniqKey="Wagner U">U Wagner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, Re" uniqKey="Coleman R">RE Coleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, Re" uniqKey="Coleman R">RE Coleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinfurt, Kp" uniqKey="Weinfurt K">KP Weinfurt</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Castel, Ld" uniqKey="Castel L">LD Castel</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fizazi, K" uniqKey="Fizazi K">K Fizazi</name></author><author><name sortKey="Carducci, M" uniqKey="Carducci M">M Carducci</name></author><author><name sortKey="Smith, M" uniqKey="Smith M">M Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parker, C" uniqKey="Parker C">C Parker</name></author><author><name sortKey="Nilsson, S" uniqKey="Nilsson S">S Nilsson</name></author><author><name sortKey="Heinrich, D" uniqKey="Heinrich D">D Heinrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sartor, O" uniqKey="Sartor O">O Sartor</name></author><author><name sortKey="Coleman, R" uniqKey="Coleman R">R Coleman</name></author><author><name sortKey="Nilsson, S" uniqKey="Nilsson S">S Nilsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="James, Nd" uniqKey="James N">ND James</name></author><author><name sortKey="Pirrie, S" uniqKey="Pirrie S">S Pirrie</name></author><author><name sortKey="Brown, Je" uniqKey="Brown J">JE Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Moos, R" uniqKey="Von Moos R">R von Moos</name></author><author><name sortKey="Body, Jj" uniqKey="Body J">JJ Body</name></author><author><name sortKey="Egerdie, B" uniqKey="Egerdie B">B Egerdie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saad, F" uniqKey="Saad F">F Saad</name></author><author><name sortKey="Gleason, Dm" uniqKey="Gleason D">DM Gleason</name></author><author><name sortKey="Murray, R" uniqKey="Murray R">R Murray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lipton, A" uniqKey="Lipton A">A Lipton</name></author><author><name sortKey="Fizazi, K" uniqKey="Fizazi K">K Fizazi</name></author><author><name sortKey="Stopeck, At" uniqKey="Stopeck A">AT Stopeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Henry, D" uniqKey="Henry D">D Henry</name></author><author><name sortKey="Vadhan Raj, S" uniqKey="Vadhan Raj S">S Vadhan-Raj</name></author><author><name sortKey="Hirsh, V" uniqKey="Hirsh V">V Hirsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patrick, D" uniqKey="Patrick D">D Patrick</name></author><author><name sortKey="Cleeland, C" uniqKey="Cleeland C">C Cleeland</name></author><author><name sortKey="Fallowfield, L" uniqKey="Fallowfield L">L Fallowfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Body, Jj" uniqKey="Body J">JJ Body</name></author><author><name sortKey="Lipton, A" uniqKey="Lipton A">A Lipton</name></author><author><name sortKey="Gralow, J" uniqKey="Gralow J">J Gralow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fizazi, K" uniqKey="Fizazi K">K Fizazi</name></author><author><name sortKey="Bosserman, L" uniqKey="Bosserman L">L Bosserman</name></author><author><name sortKey="Gao, G" uniqKey="Gao G">G Gao</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li><li>Pologne</li><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Balakumaran, A" sort="Balakumaran, A" uniqKey="Balakumaran A" first="A." last="Balakumaran">A. Balakumaran</name><name sortKey="Braun, A" sort="Braun, A" uniqKey="Braun A" first="A." last="Braun">A. Braun</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Smith, M R" sort="Smith, M R" uniqKey="Smith M" first="M. R." last="Smith">M. R. Smith</name></noRegion><name sortKey="Wang, H" sort="Wang, H" uniqKey="Wang H" first="H." last="Wang">H. Wang</name><name sortKey="Wei, R" sort="Wei, R" uniqKey="Wei R" first="R." last="Wei">R. Wei</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Coleman, R E" sort="Coleman, R E" uniqKey="Coleman R" first="R. E." last="Coleman">R. E. Coleman</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Klotz, L" sort="Klotz, L" uniqKey="Klotz L" first="L." last="Klotz">L. Klotz</name></noRegion><name sortKey="Chi, K N" sort="Chi, K N" uniqKey="Chi K" first="K. N." last="Chi">K. N. Chi</name></country><country name="Australie"><noRegion><name sortKey="Pittman, K" sort="Pittman, K" uniqKey="Pittman K" first="K." last="Pittman">K. Pittman</name></noRegion><name sortKey="Ng, S" sort="Ng, S" uniqKey="Ng S" first="S." last="Ng">S. Ng</name></country><country name="Pologne"><noRegion><name sortKey="Milecki, P" sort="Milecki, P" uniqKey="Milecki P" first="P." last="Milecki">P. Milecki</name></noRegion></country><country name="France"><noRegion><name sortKey="Fizazi, K" sort="Fizazi, K" uniqKey="Fizazi K" first="K." last="Fizazi">K. Fizazi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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